Dr. Marc Tambini Awarded NIA R01 Grant to Study the Role of APP Metabolites in Alzheimer’s Disease

Dr. Marc Tambini, Assistant Professor in the Department of Pharmacology, Physiology & Neuroscience at NJMS and core member or the Rutgers Brain Health Institute (BHI), has been awarded an R01 grant from the National Institute on Aging for his project titled “The Role of APP-Metabolites on Extracellular Vesicle Cargo and Function.”

Alzheimer’s disease is characterized by amyloid beta plaques and tau tangles, yet the cellular function of the Amyloid Precursor Protein (APP) remains unclear. This project investigates how APP metabolites are packaged into extracellular vesicles (EVs), how disease-causing mutations alter EV cargo and function, and how these changes affect tau pathology and neuron-to-neuron communication. By defining the role of APP-containing EVs in waste removal and neural signaling, this work may reveal new therapeutic targets for Alzheimer’s disease and related dementias.

Learn more: https://reporter.nih.gov/search/EGVgTh_x40y3HrwWNVExQA/project-details/11230139